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plasmablastic lymphoma
:''This article deals with plasmablastic lymphoma as defined in the WHO 2008 classification. For other entities sometimes termed plasmablastic lymphoma, see Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease and Extracavitary HHV–8-positive lymphoma''
Plasmablastic lymphoma is a type of large B-cell lymphoma, recognized in the WHO 2008 classification.〔〔〔 It is CD20 negative, and has an immunophenotype that resembles plasma cells.〔 In formal use, lymphomas with plasmablastic immunophenotype such as primary effusion lymphoma, ALK+ large B-cell lymphoma, large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease and extracavitary HHV–8-positive lymphoma are not part of this category, although sometimes the literature has confused this point.〔
==Biology==
The median age of diagnosis is approximately fourth and fifth decades.〔 The disease often arises in the oral cavity, particularly in HIV disease,〔 but other sites include nasal cavity, gastrointestinal tract, skin, bone soft tissue, and lung.〔〔〔〔 There is usually immunodeficiency, such as HIV, organ transplants, autoimmune diseases〔〔Acta Cytol. 2014;58(3):309-17. doi: 10.1159/000360359. Epub 2014 Mar 27. Extraoral plasmablastic lymphoma detected using ascitic fluid cytology and flow cytometry: a case report with a review of the literature.〕
Like Burkitt's lymphoma, the morphology has a "starry sky".〔 However, the immunophenotype resembles plasma cells: CD45-, CD20-, CD79a+/-, PAX5-, CD38+, CD38+ and MUM1+.〔 Ki67 is over 90%.〔 EBV is positive in 75%; HHV-8 is negative.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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